Action resumes across all centers in Europe as top teams in the leagues battle each other after a grueling international assignment.
As usual two London clubs will be gazing at each other in the English Premier League to earn a top four finish and a guaranteed Champions League football next season.
Two Spanish opposition who qualified into the Champions League quarter finals will come neck-to-neck on the domestic scene.
Over the years, when two of these German Bundesliga sides lock horns, and it will be a first versus third match in Munich.
Old enemies in the Italian Serie A come face to face again at the San Siro in a fixture that promises to be explosive at the weekend.
Here are the four weekend matches you can not afford to miss
1. Chelsea vs Tottenham
Antonio Conte will be looking to redeem his image when they host visiting Tottenham Hotspurs at Stamford Bridge.
Mauricio Pochetino’s side are five points ahead of their fellow Londoners who are fifth as they slug it out in the London derby.
Chelsea hope to finish the season in top four following their disappointing defence of the league as Spurs stand in their way to Champions League football next season.
2. Sevilla vs Barcelona
Sevilla have been the surprise team in the Champions League this season after coming through Manchester United in the round of 16.
However they have not been having the best of times on the domestic scene losing their last game away by 2-0 to Leganes after recording an emphatic victory against United.
Barcelona who have unbeaten will be aiming to continue their flawless run in La Liga as they will be having a taste of date with their Copa del Rey finalist.
3. Beyrn Munich vs Borussia Dortmund
The Bavarians are 18 points above their fierce rivals Dortmund in the league but there is always something to play for they both sides meet at the Allianz Arena.
Dortmund lost the reverse fixture at the Signa Iguna Park by a slim 2-1 win but they will be hoping to return the favour when they visit the German capital.
4. Juventus vs AC Milan
Just two points separate the defending champions from Napoli at the top as all the Old Lady need is to do is secure maximum points a in Turin.
However, the return of the prodigal son Leonardo Bonucci to his old club will make the contest an entertaining affair.
Gattuso’s side were knocked out of the Europa League by Arsenal but they will be looking to continue their in the Serie A.