Liverpool have Van Dijk fit again following a knock in pre-season, but neither Trent Alexander-Arnold nor captain Jordan Henderson are able to return. Tsimikas makes the bench.
Nicolas Pepe and Alexandre Lacazette are both absent for Arsenal, who include Martinez, Holding and Maitland-Niles despite reported interest from Aston Villa, Newcastle United and Wolves. Elneny, who spent last season on loan at Besiktas, also starts. Saliba is on the bench.
Subs: Adrian, Naby Keita, Marko Grujic, Curtis Jones, Takumi Minamino, Konstantinos Tsimikas, Rhian Brewster, Harvey Elliott, Billy Koumetio.
Liverpool (4-3-3): Alisson; Neco Williams, Joe Gomez, Virgil van Dijk, Andrew Robertson; James Milner, Fabinho, Georginio Wijnaldum; Mohamed Salah, Roberto Firmino, Sadio Mane.
Subs: Bernd Leno, William Saliba, Cedris Soares, Reiss Nelson, Joe Willock, Sead Kolasinac, Emile Smith Rowe, Tyreece John-Jules, James Olayinka.
Arsenal (3-4-3): Emi Martinez; Rob Holding, David Luiz, Kieran Tierney; Hector Bellerin, Mohamed Elneny, Granit Xhaka, Ainsley Maitland-Niles; Bukayo Saka, Eddie Nketiah, Pierre-Emerick Aubameyang.